Lightly grease the air fryer basket with cooking spray and preheat to 375 degrees F.
In a shallow dish, make the seasoned flour. Whisk together flour, salt, and black pepper and set aside.
In a separate shallow dish, make the egg wash. Combine the eggs and milk (or water) and beat well. Set aside next to the flour.
In a third shallow dish, make the seasoned breadcrumbs. Combine breadcrumbs, garlic powder, onion powder, ground red cayenne pepper, salt, and black pepper. Set aside next to the egg wash.
Now, coat the chicken tenders, working with one piece at a time:First, coat the chicken evenly in the flour mixture, then shake off excess flour and transfer to egg wash. Coat completely in the egg wash, then let excess egg drip off and transfer to the breadcrumbs. Coat the chicken evenly in breadcrumbs, then lightly shake off any excess breadcrumbs and set aside on a plate or a sheet of parchment paper. Once you have enough chicken tenders coated to fill the air fryer basket in a single layer, transfer them to the air fryer and cook for 14 minutes, flipping halfway through. Make sure to leave a little bit of space around each piece of chicken to ensure proper cooking.While the first batch of chicken cooks, continue dredging the remaining chicken tenders. Continue cooking the chicken in batches as necessary, greasing the basket between batches if it starts to stick.
Serve hot with your favorite dipping sauces, or let cool and store in an air-tight container in the fridge for up to 5 days.